Dr. John H. Knab is a board-certified anesthesiologist and is fellowship trained in pain management, with added qualifications in pain management from the American Board of Anesthesiologists. Dr. Knab completed his residency in anesthesiology at the Virginia Mason Medical Center in Seattle, Washington, then completed a fellowship in interventional pain management at the University of California, San Diego. He has practiced pain medicine exclusively at the Center for Pain Management since 2000, where he is currently the Medical Director. Dr. Knab specializes in all aspects of interventional pain medicine and has a special interest in autologous cell-based therapies.

Dr. Thomas Buchheit completed his residency in anesthesiology and perioperative care at the University of California, San Francisco, and his fellowship in interventional pain management at Wake Forest University. During the first decade of his career, he cared for patients with spine and joint disease in private practice.

In 2010, he moved his practice to Duke University, where he began studying nerve injury pain and served as Chief of Pain Medicine. During his academic career, Dr. Buchheit investigated the immune basis of pain relief following injury and the mechanisms behind regenerative therapies, including platelet-rich plasma, stem cells, and autologous conditioned serum. He has led several studies funded by the National Institutes of Health and the Department of Defense.

In 2025, Dr. Buchheit founded Triangle Regen Medicine and Biologics Center in Chapel Hill, NC, to bring a wide range of regenerative therapies to patients. He now serves as an adjunct associate professor at Duke and continues to work with scientists at the Center for Translational Pain Medicine.

Dr. Navneet Boddu is Board Certified in Pain Medicine, Anesthesiology and is a Fellowship-trained Pain Management specialist. Dr. Boddu has been practicing Interventional Pain Management for more than 25 years. He is a specialist in Regenerative Medicine and an expert in stem cell therapies and PRP treatments. He uses leading edge technology in Regenerative Medicine to treat patients with spine and joint disorders. Dr. Boddu completed his ACGME accredited Anesthesiology residency at Loma Linda University School of Medicine in 1997 and was awarded the Outstanding Graduate Resident of the Year of his graduating class. Dr. Boddu completed ACGME accredited fellowship in Pain Management at the University of California, Davis, Medical Center, in 1998.

He has a distinguished career in the medical field in San Diego County. In 2024, he was recognized as a Top Doctor in Pain Medicine by San Diego Magazine. He was also recognized as a Top Doctor in Pain Medicine and Anesthesiology by San Diego Magazine in the years 2023, 2022, 2021 and 2017. He was chairman of the anesthesiology department at Tri-City Medical Center from 2015 to 2017

Dr. Ashu Goyle is a double board-certified anesthesiologist and interventional pain specialist with a fellowship in Pain Medicine from the Cleveland Clinic, where he trained under leading experts in the field. He has a strong background in both acute and chronic pain management and has been recognized for outstanding patient care during his residency.

Dr. Goyle focuses on providing individualized care through non-narcotic, minimally invasive techniques to help patients regain optimal health. He also has a keen interest in holistic and functional medicine, advocating for lifestyle changes and nutritional support as part of comprehensive care.

Practicing in Scottsdale, Arizona since 2008, Dr. Goyle has earned the “Top Doc” in Pain Management distinction from Phoenix Magazine multiple times from 2011 to 2020. His pain management approach includes spinal injections, radiofrequency ablation, neuromodulation, and lifestyle modifications, with a particular interest in regenerative medicine.

He is double board-certified by The American Board of Anesthesiologists and is an active member of several professional organizations, including the American Society of Anesthesiologists and the Institute for Functional Medicine.

Dr. Tammy Penhollow is a board-certified pain management and regenerative medicine specialist at Precision Regenerative Medicine in Scottsdale, Arizona. She is highly skilled in ultrasound and fluoroscopy-guided joint, spine, and aesthetic procedures.

Dr. Penhollow earned her medical degree from Kirksville College of Osteopathic Medicine (now AT Still University) and began her U.S. Navy career after completing her internship at Sacred Heart Medical Center in Spokane. She served in Kosovo as a battalion physician and later as an instructor at the Navy’s Independent Duty Corpsman School.

She completed an anesthesiology residency at Walter Reed/National Naval Medical Center and a fellowship in Pain Medicine at Stanford. Her Navy service included staff anesthesiologist roles in Okinawa and Spain, where she established chronic pain clinics, and a deployment to Djibouti in support of Operation Enduring Freedom.

Her clinical focus is regenerative medicine and whole-body wellness.

Dr. Osman earned his medical degree at the University of Missouri-Kansas City by completing their prestigious and highly competitive BA/MD Combined 6 year Accelerated Program – one of the few of its type in the country. This meant, from the age of 18, with great motivation and endurance, Dr. Osman studied for both his Bachelors and Medical School training. Dr. Osman continued his medical training by completing his Residency in Anesthesiology at the University of Florida College of Medicine in Gainesville, Florida. He then achieved his Fellowship in Pain Medicine at Beth Israel Deaconess Medical Center at Harvard Medical School.

Creating meaningful and genuine relationships with his patients, empowering them to be involved in the decisions surrounding their care and understanding the importance of c reating a warm and transparent physician-patient relationship has been the hallmark of Dr. Osman’s practice. This personable and dynamic nature has been recognized multiple times over: he was named Resident of the Month on three separate occasions whilst at the University of Florida as well as being awarded Interventional Pain Fellow of the Year of his graduating class by Harvard Medical School. This nature has followed him into his practice as a pain management specialist where he has been described as “upbeat”, “compassionate” with “magnetic personality” , taking the “time to explain information clearly” and “always concerned about your care. ”

Dr. Osman has been recognized as a Castle Connolly Top Doctor for both 2024 and 2025 and has received awards as a top pain physician within the UPMC hospital system. His approach to care is centered around empowering patients through education, compassion, and trust. Known for his warm, personable, and engaging demeanor, Dr. Osman has been consistently praised for taking the time to explain complex information clearly and making every patient feel heard and valued.

Dr. Ariana DeMers is a fellowship-trained orthopedic sports medicine surgeon and regenerative medicine expert dedicated to redefining how musculoskeletal and longevity care are delivered. As the founder of the Joint Vitality Institute at Restore Orthopedics and Sports Medicine, she has pioneered a patient-centered approach that blends orthobiologic precision, hormonal optimization, and lifestyle medicine to help patients stay active, age vibrantly, and avoid unnecessary surgery.

A recognized leader in the field, Dr. DeMers serves as Chief of Medical Education for APEX Biologix, Vice President of the International Association of Regenerative Medicine & Education Society (IARMES), and past president and board member of the Interventional Orthobiologics Foundation. Her mission extends beyond clinical excellence - she empowers physicians worldwide to build sustainable, ethical, cash-based practices through her educational platforms The Business of Orthobiologics (BOB), PRP Now, and the Orthobiologic Practice Launch System.

Known for her clarity, innovation, and integrity, Dr. DeMers has trained thousands of clinicians in ultrasound-guided injection techniques, PRP dosing, and evidence-based orthobiologic protocols. She is a frequent national and international speaker, advisor to leading biologic and device companies.

Through her integrated ecosystem of clinics, courses, and collaborations, Dr. DeMers is shaping the next era of regenerative orthopedics - one defined by scientific excellence, patient empowerment, and physician freedom.

Dr. Dregalla holds a Ph.D. in Cell and Molecular Biology from Colorado State University, earned in 2011. His graduate research, funded by NASA, focused on telomere and DNA-repair proteins and their role in chromosomal stability following exposure to ionizing radiation.

After completing his doctorate, Dr. Dregalla helped develop a functional research program supporting a physician-owned autologous cell therapy clinic, where he discovered a strong interest in orthobiologics and tissue-based therapies. Beginning in 2014, his work has centered on the development of human-derived acellular tissue products designed to address unmet needs in wound care. He aims to extend these scientifically grounded technologies into orthopedics, a field where high-quality, evidence-based tissue solutions remain limited.

Since 2019, Dr. Dregalla has collaborated with startup ventures, established medical device companies, and physicians, providing laboratory-based services supporting QA/QC, peer-reviewed research, intellectual property development, and FDA regulatory filings.

Dr. Chopra is a dual board-certified Physical Medicine & Rehabilitation and Pain Management physician.

Dr. Chopra earned a combined BA/MD degree from the University of Missouri-Kansas City and completed her medical residency in the Department of Physical Medicine and Rehabilitation at the University of Kentucky. She completed her fellowship in Pain Medicine at MD Anderson Cancer Center in Houston, TX.

Dr. Chopra treats chronic pain, including musculoskeletal pain, neurological pain, and cancer pain. To perform optimal patient care, she offers each patient an individualized interventional treatment plan that may include tailored physical therapy, medication management, and interventional procedural treatments. Dr. Chopra uses cutting-edge technology to help her patients experience lasting relief from pain. She does this without the need for invasive surgery or potentially addictive pain medications.

Dr. Chopra’s dedication to relieving pain, restoring range of motion, and improving her patients’ mobility and flexibility extends to minimally invasive surgery, including the Vertiflex™ Procedure and Mild® Procedure. She also performs various interventional procedures, including implantable spinal cord stimulation, intrathecal drug delivery systems, vertebral augmentation, and more. She is a published author on various topics in pain medicine and teaches physicians across the country about new cutting-edge procedures.

Dr. George Chang Chien specializes in musculoskeletal medicine and comprehensive pain management. He was trained in Physical Medicine & Rehabilitation at the Rehabilitation Institute of Chicago, the #1 Ranked Rehabilitation Hospital in the United States since 1991.

After completion of his Physiatry training, he completed fellowship training in comprehensive pain medicine at the prestigious Cleveland Clinic Anesthesiology Institute. One of the top graduates of his class at Western University of Health Sciences, he was elected President of Sigma Sigma Phi, the Osteopathic medical school honor and service society. Dr. Chang Chien has authored over 120 manuscripts on the diagnosis and treatment of pain and musculoskeletal conditions. He has active research in regenerative medicine applications for chronic pain, medical aesthetics, and musculoskeletal medicine.               

His professional ultrasound teaching experience in musculoskeletal and interventional pain management includes Course Director at the Cleveland Clinic Pain Medicine Annual Ultrasound Course, Course Director for the Ultrasound for Regenerative Medicine for the American Society of Interventional Pain Physicians (ASIPP) workshop, Apex Biologix, Dannemiller, and the Society for Pain Practice Management (SPPM).

Dr. Chang Chien specializes in regenerative medicine with expertise in platelete rich plasma (PRP), bone marrow aspiration for stem cells (BMAC), and adipose derived stem cells (ADSC). He is also an expert in comprehensive pain management, non-surgical orthopedics, and functional restoration. He is currently the Director of Pain Management at Ventura County Medical Center, Director of Center Regenerative Medicine at Southern California University, and serves alongside Sudhir Diwan MD, as the Regenerative Medicine Section Co-Editor for Pain Physician Journal.

Dr. Glenn M. Flanagan completed his residency in Anesthesiology and Interventional Spine fellowship at Syracuse University in Upstate New York.

In 2019 he opened his own hybrid practice at Naples Regenerative Institute, pledging to offer his patients an integrative blend of traditional pain management treatments and state-of-the-art orthobiologic injections such as platelet-rich plasma (PRP) and stem cell treatments. He specializes in fluoroscopy and ultrasound guided treatments of the spine and musculoskeletal system.

Alongside his growing practice he has helped support the growth of orthobiologics through presenting and teaching at numerous conferences, publishing research and as an author in the field.

Loren Deren, MS, CTBS is Vice President of Clinical Development at APEX Biologix, bringing over 15 years of experience in medical devices, orthobiologics, and regenerative medicine. With a background spanning clinical education, business development, and sales, she is dedicated to advancing clinical outcomes through innovation, research, and strategic partnerships. Loren holds a Master of Science in Biotechnology and is committed to driving growth through cutting-edge clinical education and regenerative medicine solutions.